Vascular anomalies are abnormalities or disorders of veins, arteries, and lymphatic channels, and it encompasses a spectrum of rare diseases that can be classified into vascular tumors or vascular malformations. Vascular anomalies can be treated with a combination of procedures, surgeries, and medical therapies. However, many of the current medical therapies used for vascular anomalies were not originally made for these rare diseases, so the mechanistic understanding of what drives the clinical benefit in vascular anomalies is limited. This presentation aims to inform attendees on clinical research being conducted for the benefit of pediatric patients with vascular anomalies, with an emphasis on the clinical research I’ve conducted in lymphatic anomalies and infantile hemangioma at the Vascular Anomalies Center and Bischoff Lab at Boston Children’s Hospital.