Treatment for parasitic worms in animals is a common practice in veterinary medicine. Additionally, anthelmintics are a group of antiparasitic drugs that paralyze or kill the given parasite without causing any significant damage or harm to the host. This study focuses on three specific parasite preventatives commonly administered to animals which includes, Ivermectin, Albendazole, and Pyrantel. Furthermore, an N2 stain of C. elegans (microscopic worms) were utilized as models for various parasitic worms in order to gain a better understanding of how gene expression is altered when treated and exposed to varying concentrations of antihelminthic drugs. This study incorporated mixed investigations consisting of qPCR (quantitative real-time polymerase chain reaction), behavioral assays, western blots, and imaging through confocal microscopy. The scientific findings and variation in data from the results of these studies ultimately led to inconclusive results and conclusions. However, the primary purpose of these observations are to potentially elucidate resistance factors of these nematodes, which can possibly improve the effectiveness of antihelminthic drugs in actual parasitic worms.
